Note ( 10 E , 12 Z , 15 Z ) - 9 - Hydroxy - 10 , 12 , 15 - octadecatrienoic Acid Methyl as an Anti - inflammatory Compound from Ehretia dicksonii JSBA Ester
نویسندگان
چکیده
flammatory compound. Compound 1 suppressed 12-Otetradecanoyl-phorbol-13-acetate (TPA)-induced infiammation on mouse ears at a dose of 500vg (the i"hibitory effect (IE) was 43%). Linolenic acid methyl ester did not inhibit this infiammation at the same dose. Howeyer, the related compounds of 1, (9Z,11E)-13hydroxy-9,11-octadecadienoic acid (5) and (9Z,11M13-oxo-9,11-octadecadienoic acid (6), sltowed potent
منابع مشابه
Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA.
We have recently described a di-hydroxylated compound called protectin DX (PDX) which derives from docosahexaenoic acid (DHA) by double lipoxygenation. PDX exhibits anti-aggregatory and anti-inflammatory properties, that are also exhibited by similar molecules, called poxytrins, which possess the same E,Z,E conjugated triene geometry, and are synthesized from other polyunsaturated fatty acids w...
متن کاملFatty acid composition of seeds of Satureja thymbra and S. cuneifolia.
The chemical composition of fatty acid methyl esters (FAMEs) from seeds of S. thymbra and S. cuneifolia were analyzed by GC/MS. 7 FAMEs were identified from the seeds of S. thymbra mainly as 9-octadecenoic acid methyl ester (43.9%), hexadecanoic acid methyl ester (11.4%), 9,12,15-octadecatrienoic acid methyl ester (Z,Z,Z) (30.2%), and octadecanoic acid methyl ester (14.1%), while from the seed ...
متن کاملProduction of novel tetrahydroxyfuranyl fatty acids from alpha-linolenic acid by Clavibacter sp. strain ALA2.
Previously, it was reported that a newly isolated microbial culture, Clavibacter sp. strain ALA2, produced trihydroxy unsaturated fatty acids, diepxoy bicyclic fatty acids, and tetrahydroxyfuranyl fatty acids (THFAs) from linoleic acid (C. T. Hou, J. Am. Oil Chem. Soc. 73:1359-1362, 1996; C. T. Hou and R. J. Forman III, J. Ind. Microbiol. Biotechnol. 24:275-276, 2000; C. T. Hou, H. Gardner, and...
متن کاملAnaerobic lipoxygenase activity from Chlorella pyrenoidosa.
The micro-alga Chlorella pyrenoidosa expresses an enzymatic activity that cleaves the 13-hydroperoxide derivatives of linoleic acid [13-hydroperoxy-9(Z),11(E)-octadecadienoic acid, 13-HPOD] and linolenic acid [13-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid, 13-HPOT] into volatile C(5) and non-volatile C(13) oxo-products. This enzymic activity initially was attributed to a hydroperoxide l...
متن کاملMETHODS Method to Produce 9(S)-Hydroperoxides of Linoleic and Linolenic Acids by Maize Lipoxygenase
Seed from maize (corn) Zea mays provides a ready source of 9-lipoxygenase that oxidizes linoleic acid and Iinolenic acid into 9(5)-hydroperoxy-1 0(8, 12(Zl-octadecadienoic acid and 9(SJ-hydroperoxy-1 0(£), 12(Zj, 15(Zl-octadecatrienoic acid, respectively. Corn seed has a very active hydroperoxide-decomposing enzyme, allene oxide synthase (AOS), which must be removed prior to oxidizing the fatty...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2018